Synthesis of quinolines and their In vitro antioxidant activities under solvent free conditions by using the SiO2-Zn-MgO as a novel and reusable catalyst.

The present study was aimed to determine a novel route of synthesis of quinolines and their in vitro antioxidant activities. Synthesis of quinolines is simple, economic, effective and an easy way process has been developed by using the SiO2–Zn-MgO as a novel catalyst. The quinolines antioxidative potential was evaluated using 1,1-Diphenyi-2-Picrylhydrazyl (DPPH), superoxide radical, hydroxyl radical, and hydrogen peroxide radical assay by in vitro methods. Quinolines exhibited highest level of antioxidant activities, and therefore it could be used as antioxidant that may have potential benefits in health and disease management.

Periosteal Pedicle Graft : A Promising Technique For The Treatment of Gingival Recession Defects.

The periosteum is a rich vascular connective tissue with great regenerative potentiality. The qualities of periosteum make it an ideal autogenous graft. The present case report describes the utilisation of periosteal pedicle graft for the treatment of gingival recession defect successfully.

The effect of ibuprofen on bleeding during periodontal surgery.

BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used medications for both medical and dental ailments. These drugs have been shown to increase bleeding during surgeries, which may prompt practitioners to discontinue their use before surgical procedures. The aim of the present study is to assess the effect of a common NSAID, ibuprofen, on bleeding during periodontal surgery. MATERIALS AND METHODS: The study group consisted of 10 patients who were scheduled to undergo periodontal surgery of similar type, complexity, and duration. Each subject acted as control as well as case group. The case group consisted of 10 surgeries in which patients were administered ibuprofen prior to surgery, whereas ibuprofen was not administered in control group. Bleeding time was measured at first visit and prior to first and second surgeries. The volume of blood loss during each surgery was measured by subtracting the amount of water used for irrigation from the total volume of fluid collected in the portable aspirator at the end of the surgery. RESULTS: The result showed a statistically significant (P < 0.05) increase in intraoperative bleeding during periodontal surgery when ibuprofen was preadministered. In addition, there was statistically significant (P < 0.05) increase in bleeding time. CONCLUSION: Ibuprofen taken prior to periodontal surgery increases intraoperative bleeding and should be administered cautiously before periodontal surgeries.

Impaired gestational glucose tolerance. Its effect on placental pathology

The aim of this study was to investigate several macroscopic and microscopic features of placenta in cases with impaired gestational glucose tolerance. Seventy-five gm World Health Organization criteria for the diagnosis of gestational diabetes and impaired gestational glucose tolerance were followed during the period June 1999 through to June 2000, at the Maternity Hospital of Kuwait. Macroscopic and microscopic examinations of 95 placentas were carried out. Sixty-five were from the control patients and 30 were from cases with impaired gestational glucose tolerance. Mean maternal age, maternal weight and parity was significantly higher in the impaired gestational glucose tolerance [IGGT] group compared to the control group. Mean birth weight of the baby was significantly higher in the IGGT group compared to the control group. Mean placental weight and the percentage of the cesarean delivery was higher in the IGGT group but did not reach the level of significance. There was no significant association between the microscopic features of the placenta in the control and IGGT groups. Impaired gestational glucose tolerance is related to increased neonatal and placental weight, which may lead to a higher number of cesarean deliveries, stressing the similarity between impaired gestational glucose tolerance and gestational diabetes mellitus. More stringent criteria may be necessary to define gestational diabetes. Microscopic features of placenta both in the control and IGGT groups did not show any significant difference

Clinical presentation of eclampsia in a maternity hospital, Kuwait

To identify the clinical features of eclampsia at the time of the fit and to study the effects of eclampsia on neonatal outcome. A retrospective study of 101 patients with eclampsia in Al-Sabah Maternity Hospital of Kuwait between 1981 and 1993 was undertaken. Seventy one percent of the mothers presented with antepartum eclampsia. Adverse perinatal outcome was associated with low gestation age, birth weight below 2500g and when the antepartum fit occurred >5 hours before delivery. The perinatal outcome was also adversely affected by fetal gender [male] and proteinuria of 2+ or more. Early onset of pre eclamptic toxemia and eclampsia leading to early intervention are a major determinant to perinatal outcome and prematurity. Prompt timing of the delivery in cases of antepartum fit could help improve the neonatal outcome considerably. It seems that pre eclamptic toxemia is the major risk factor for eclampsia when compared with pregnancy induced hypertension. However, treating all cases of pre-eclampsia toxemia involves giving prophylaxis for more than 5% of all mothers per year. Therefore, one needs to study the details of cases of pre eclamptic toxemia and eclampsia to detect the additive factors. This would help to delineate guidelines and identify patients who need prophylaxis and the appropriate time for intervention

Isolation and characterization of a naturally occurring inhibitor from mung bean (Vigna radiata) seedlings for serine hydroxymethyltransferase.

A naturally occurring inhibitor of serine hydroxymethyltransferase (EC 2.1.2.1) in mung bean seedlings extracts was purified by ammonium sulphate precipitation, phenyl-Sepharose chromatography followed by heating to release the inhibitor bound to the protein. The inhibitor had an absorption maximum at 200 nm, was not precipitated by trichloroacetic acid, was dialysable and resistant to inactivation by heating at 98 degrees C for 4 hr, protease and ribonuclease digestion; but was acid labile. The chromatographically pure preparation inhibited both mung bean and sheep liver SHMT. Qualitative and quantitative analyses indicated that it contained a carbohydrate moiety, an O-amino and vicinal diol groups. Paper electrophoresis at pH 4.3 suggested that the inhibitor was positively charged.